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Skin texture
Polynucleotide treatments may help improve the appearance of uneven skin texture and skin quality.
Polynucleotide treatments in Bromley
Better skin. From within.
Discover a regenerative approach to skin rejuvenation with polynucleotide treatments at Coull Aesthetics. Designed to support skin quality and natural renewal, without changing your facial features.
Nurse-led treatments · Individual assessment required
PLINEST®
Regenerative Skin Care
Focused on supporting skin quality
Natural-Looking Changes
Gradual improvement rather than added volume
Independent Nurse Prescriber
Clinically informed, personalised treatment
Skin regeneration
Understanding the treatment
Science meets skin renewal.
Polynucleotides are purified chains of nucleotides, the building blocks of DNA. In aesthetic medicine, injectable polynucleotide products are used to support the skin's natural repair processes.
Unlike traditional dermal fillers, their main purpose is not to add volume or reshape facial features.
Instead, polynucleotide treatments aim to improve aspects of skin quality, including texture, hydration and elasticity. Improvements typically develop gradually, and results vary between individuals.
At Coull Aesthetics, Orla uses PLINEST® treatments as part of a personalised approach to regenerative skin care.
Skin quality
Focused on overall skin condition
Gradual care
Changes develop over a course of treatment
A more considered approach
It's not about looking younger.
It's about looking after your skin.
Skin changes are a natural part of life. Our goal is to support healthier-looking skin through thoughtful, medically led treatments that work with your individual needs and expectations.
Skin-focused benefits
A thoughtful way to care for your skin.
Polynucleotides are used in regenerative aesthetics for several skin concerns. Potential benefits depend on the individual, treatment area and product selected.
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Fine lines
May soften the appearance of some superficial lines as part of a gradual skin rejuvenation plan.
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Skin elasticity
Aims to support skin firmness and resilience where age-related changes have become noticeable.
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Delicate skin
May be considered for fragile-looking skin in selected areas, following assessment and suitability checks.
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Skin hydration
May support improved moisture balance and the appearance of healthier-looking skin.
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Regenerative support
Used in aesthetic medicine to support natural tissue repair processes and gradual renewal.
Where treatment may help
Different areas. One individual approach.
Polynucleotides may be used in several areas where skin quality is a concern.
Select an area to learn more. Orla will determine whether treatment is appropriate after assessing your skin and medical history.
Facial skin quality
Polynucleotides may be considered for concerns such as uneven texture, fine lines and loss of skin elasticity. Treatment focuses on skin quality rather than changing facial contours.
Individual assessment requiredDelicate under-eye skin
Carefully selected polynucleotide treatments may be suitable for fine lines and poor skin quality around the eyes. Not all under-eye concerns respond to this treatment.
Product and suitability depend on assessmentNeck & décolletage
These areas can develop visible changes in texture and elasticity over time. A personalised consultation will determine whether regenerative treatment may be suitable.
Appropriate product selection is essentialSkin on the hands
Hands can show age-related changes in skin quality and texture. Treatment may be considered in selected cases, depending on suitability and the available product protocol.
Discuss available options with Orla
The treatment at Coull Aesthetics
Introducing PLINEST®.
PLINEST® is a polynucleotide-based injectable treatment used in regenerative aesthetic medicine.
Its purpose is to support the skin's natural regenerative processes, with a focus on improving skin quality rather than introducing facial volume.
At Coull Aesthetics, Orla will assess your concerns and explain whether PLINEST® or another treatment is appropriate for your individual goals.
- Focused on skin health and rejuvenation
- Gradual, natural-looking changes
- Personalised treatment planning
- Medically informed consultation and aftercare
What to expect
Your treatment. Thoughtfully delivered.
Every appointment is centred around your comfort, safety and understanding of the treatment process.
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Personal consultation
Orla will discuss your skin concerns, medical history and expectations, assess the treatment area and explain whether polynucleotides are suitable.
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Your appointment
If you decide to proceed, the skin is prepared and the treatment is administered through a series of small injections. Numbing cream may be used to improve comfort.
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Aftercare & review
You'll receive individual aftercare advice and information about expected recovery. Progress and any further sessions can be reviewed together.
A gradual approach
Good things take time.
Polynucleotide treatments are generally planned as a course rather than a single appointment.
Coull Aesthetics typically recommends an initial course of three sessions, approximately two to four weeks apart, with maintenance considered according to individual response and goals.
This is an example of the clinic's usual approach, not a guaranteed schedule or outcome.
View Treatment Prices
First appointment
Session one
Your initial treatment follows a consultation and suitability assessment. Aftercare advice is provided before you leave.
Approximately 2 to 4 weeks later
Session two
The next session is planned around your skin's response and the recommended treatment protocol.
Another 2 to 4 weeks later
Session three
The initial course is completed where appropriate, with progress reviewed and future care discussed.
Longer-term maintenance
Ongoing skin care
Further sessions may be considered over time. Orla will recommend maintenance only when appropriate.
Your wellbeing comes first
Clinical care. Clear guidance.
Like all injectable procedures, polynucleotide treatments involve potential side effects and risks. Understanding these is an important part of making an informed choice.
What might happen afterwards?
Temporary redness, swelling, small bumps, tenderness and bruising may occur around injection sites.
The amount of downtime varies. Although recovery is often relatively short, your skin may need time to settle.
Orla will give you specific aftercare instructions, explain warning signs and advise when to seek further medical attention.
Seek prompt medical advice if you
develop severe or worsening pain,
spreading redness, fever, signs of
infection or other unexpected symptoms.
Contact emergency services for symptoms
of a severe allergic reaction.
Is treatment suitable for everyone?
Not necessarily. A full assessment is required before proceeding. Important considerations include:
- Pregnancy or breastfeeding
- Allergies, including fish-derived ingredients where relevant
- Active skin infections or inflammation
- Autoimmune conditions or relevant medical history
- Medications affecting bleeding or bruising
- Previous cosmetic or injectable treatments
- Individual treatment goals and expectations
Orla will review product-specific contraindications and may advise against treatment when appropriate. Do not stop prescribed medication without advice from your prescriber.
Frequently asked questions
A little more clarity.
Considering polynucleotides for the first time? Explore some common questions about the treatment and what to expect.
View All FAQsHow do polynucleotides work?
Polynucleotides are used to support
regenerative processes in the skin.
They are being studied for potential
improvements in skin texture,
hydration and elasticity.
The strength of evidence varies
by product and treatment indication.
Are polynucleotides the same as dermal fillers?
No. Hyaluronic acid dermal fillers
are commonly used to restore volume
or alter facial contours.
Polynucleotides are primarily used
with the aim of supporting skin
quality and regenerative processes.
How many sessions will I need?
Coull Aesthetics commonly recommends
an initial course of three sessions,
usually spaced two to four weeks apart.
Your individual plan will be
confirmed during consultation.
Is the treatment painful?
Some discomfort can occur with
injections. Numbing cream may be
applied beforehand to improve
comfort. Sensitivity varies
between individuals and areas.
When will I see results?
Changes are generally gradual
rather than immediate. Several
sessions may be recommended,
and some people may notice
limited improvement. Results
cannot be guaranteed.
Can polynucleotides be used under the eyes?
Certain polynucleotide formulations
may be considered for delicate
under-eye skin, depending on
individual suitability and the
specific product used.
A consultation is essential.
How much do polynucleotides cost?
Prices depend on the product,
treatment area and course.
Please visit our
treatment price list
or contact Orla to discuss
your options.
Your skin deserves thoughtful care
Let's talk about your skin.
Book a complimentary consultation with Orla to discuss polynucleotides, explore treatment suitability and receive honest, personalised advice.
Book Your Consultation